Obtaining a dry extract of pterodon emarginatus (Fabaceae) fruits by spray-drying
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Data
2012-01
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Resumo
The Pterodon emarginatus presents some pharmacological properties that may be related to the presence of vouacapanes. The purpose of this work is to
reach a standardized dry extract of the P. emarginatus fruit. The powder, ethanolic extract and dry extract showed the presence of vouacapanes and lupeol
confirmed by IR and GC-MS. The drying process (spray drying) using the colloidal silicon dioxide showed to prevent the thermal degradation and increased
approximately twice the terpenes content. The scanning electron microscopy (SEM) showed irregular and spherical particles. The analytical method by
spectrophotometry for the quantification of total terpenes was validated and showed to be selective, linear, precise, accurate and robust. In the antinociceptive
activity test (capsaicin), the pre-treatment with the dried extract reduced the reactivity time in 50.9%. The results may suggest that the technological
processes employed to transform the P. emarginatus fruits in standardized dried extract were adequate to maintain quality chemistry and antinociceptive
activity described for the fruits. This work represents the first description of the obtaining of the standardized dried extract of P. emarginatus and also the
identification of lupeol in the fruits of this medicinal plant.
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Medicinal plant, Antinociceptive, Quality control, Spray drying, Technological processes
Citação
OLIVEIRA,Patrícya C. et al. Obtaining a dry extract of pterodon emarginatus (Fabaceae) fruits by spray-drying. Journal of Pharmacy Research, Kharar, v. 5, n. 1, p. 641-645, Jan. 2012.