Comparison between the 1% and 2% ibopamine provocative test in primary open-angle glaucoma patients: sensitivity, specificity and tolerability
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Data
2006
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Resumo
Purpose: To compare intraocular pressure (IOP) rise in normal individuals
and primary open-angle glaucoma patients and the safety and efficacy of
ibopamine eye drops in different concentrations as a provocative test for
glaucoma.Methods:Glaucoma patients underwent (same eye) the ibopamine
provocative test with two concentrations, 1% and 2%, in a random
sequence at least 3 weeks apart, but not more than 3 months. The normal
individuals were randomly submitted to one of the concentrations of
ibopamine (1% and 2%). The test was considered positive if there was an
IOP rise greater than 3 or 4 mmHg at 30 or 45 minutes to test which subset
of the test has the best sensitivity (Se)/specificity (Sp). Results: There was
no statistically significant difference in any of the IOP measurements,
comparing 1% with 2% ibopamine. The IOP was significantly higher at 30
and 45 minutes with both concentrations (p<0.001). The best sensitivity/
specificity ratio was achieved with the cutoff point set as greater than 3
mmHg at 45 minutes with 2% ibopamine (area under the ROC curve: 0.864,
Se: 84.6%; Sp:73.3%). All patients described a slight burning after
ibopamine’s instillation. Conclusion: 2% ibopamine is recommended as a
provocative test for glaucoma. Because both concentrations have similar
ability to rise IOP, 1% ibopamine may be used to treat ocular hypotony.
Descrição
Palavras-chave
Dopamine Agonists/administration & dosage, Glaucoma, open-angle/diagnosis, Intraocular pressure/drug effects, Sensitivity and specificity, Ophthalmic solutions, Agonistas dopaminérgicos/administração & dosagem, Glaucoma de ângulo aberto/diagnóstico, Sensibilidade e especificidade, Pressão intraocular/efeito de drogas, Tolerância e eficácia, Soluções oftálmicas
Citação
MAGACHO, Leopoldo et al. Comparison between the 1% and 2% ibopamine provocative test in primary open-angkle Glaucoma patients: sensitivity, specificity and tolerability. Arquivos Brasileiros de Oftalmologia, São Paulo, v. 69, n. 5, p. 695-699, 2006.