Diferentes terapias no tratamento da obesidade em pacientes hipertensos
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Data
1996
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Resumo
Purpose - To evaluate the efficacy and tolerability of
different therapies associated with diet in the treatment of
hypertensive obese patients.
Methods - In a clinical study we randomly evaluated
39 hypertensive obese patients (body mass index (BMI)
>30kg/m 2 ). After 45 days of diet the patients were again
randomly distributed in 3 groups and received in double
blind way: group 1 - hypocaloric diet + placebo; group 2
- hypocaloric diet + dexfenfluramine; group 3 -
hypocaloric diet + spiruline+fucus+gelatine. We followed
their progress during 12 weeks under medication and
further 24 weeks without. We evaluated the groups
comparing: weight, BMI, blood pressure and side-effects.
Results - Twenty seven patients completed the obser-
vation. In those patients from groups 1 and 3 no changes in
any of parameters were observed. In group 2 we observed
a clear loss of weight (-3.8Kg) and a fall in BMI. Blood
Pressure changes were only observed in group 2 (-9.6%).
The only patients to maintain weight loss after the
termination of use of medicines were those from group 2.
We did not observe any side-effects.
Conclusion - In hypertensive obese patients, when
isolated diet is not enough to control weight loss, dexfenflu-
ramine could be useful in association with a controlled
diet. The drug assists in weight loss, does not promote side-
effects and does not interfere in the treatment of blood pres-
sure.
Descrição
Palavras-chave
Obesidade, Tratamento, Hipertensão, Obesity, Treatment, Hypertension
Citação
MONEGO, Estelamaris Tronco et al. Diferentes terapias no tratamento da obesidade em pacientes hipertensos. Arquivos Brasileiros de Cardiologia, São Paulo, v. 66, n. 6, p. 343-347, 1996.