Isolation and structural characterization of two new furanoditerpenes from Pterodon emarginatus (Fabaceae)
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2017
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Resumo
A furanoditerpene-enriched fraction was obtained from the fruits of Pterodon emarginatus
and submitted to semipreparative high performance liquid chromatography (HPLC). Two
new furanoditerpenes, 6α,19β-diacetoxy-7β,14β-dihydroxyvouacapan and 6α-acetoxy7β,14β-dihydroxyvouacapan, in addition to the known compound methyl 6α-acetoxy7β-hydroxyvouacapan-17β-oate were obtained. Compound structures were determined by 1D
and 2D nuclear magnetic resonance (NMR) experiments and electrospray ionization Fourier
transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS). The major compound
methyl 6α-acetoxy-7β-hydroxyvouacapan-17β-oate was evaluated against promastigote forms of
Leishmania amazonensis and L. braziliensis, presenting the concentration which causes lysis on
50% of parasites IC50 < 30 µg mL-1.
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Pterodon, Furanoditerpenes, Vouacapan, Leishmania
Citação
OLIVEIRA, Leandra A. R. et al. Isolation and structural characterization of two new furanoditerpenes from Pterodon emarginatus (Fabaceae). Journal of the Brazilian Chemical Society, Campinas, v. 28, n. 10, p. 1911-1917, 2017. DOI: 10.21577/0103-5053.20170029. Disponível em: https://s3.sa-east-1.amazonaws.com/static.sites.sbq.org.br/jbcs.sbq.org.br/pdf/2016-0749AR.pdf. Acesso em: 21 jun. 2023.