Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma
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Data
2009
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Resumo
Due to the highly glycolytic metabolism of solid tumours, there is an increased acid production, however, cells
are able to maintain physiological pH through plasma membrane efflux of the accumulating protons. Acid efflux through
MCTs (monocarboxylate transporters) constitutes one of the most important mechanisms involved in tumour intracellular pH
maintenance. Still, the molecular mechanisms underlying the regulation of these proteins are not fully understood. We aimed
to evaluate the association between CD147 (MCT1 and MCT4 chaperone) and MCT expression in cervical cancer lesions and
the clinico-pathological significance of CD147 expression, alone and in combination with MCTs. The series included 83 biopsy
samples of precursor lesions and surgical specimens of 126 invasive carcinomas. Analysis of CD147 expression was performed
by immunohistochemistry. CD147 expression was higher in squamous and adenocarcinoma tissues than in the non-neoplastic
counterparts and, importantly, both MCT1 and MCT4 were more frequently expressed in CD147 positive cases. Additionally,
co-expression of CD147 with MCT1 was associated with lymph-node and/or distant metastases in adenocarcinomas. Our results
show a close association between CD147 and MCT1 and MCT4 expressions in human cervical cancer and provided evidence for
a prognostic value of CD147 and MCT1 co-expression.
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CD147, Cervical carcinoma, Monocarboxylate transporters
Citação
PINHEIRO, Celine Pinheiro et al. Monocarboxylate transporters 1 and are associated with CD 147 in cervical carcinoma. Disease Markers, London, v. 26, n. 3, p. 97-103, 2009.