Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma

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dc.creatorPinheiro, Céline Marques
dc.creatorLongatto Filho, Adhemar
dc.creatorPereira, Sônia Maria Miranda
dc.creatorColonelli, Daniela Etlinger
dc.creatorMoreira, Marise Amaral Rebouças
dc.creatorRibeiro, Luiz Fernando Jubé
dc.creatorQueiroz, Geraldo Silva
dc.creatorSchmitt, Fernando Carlos de Lander
dc.creatorBaltazar, Fátima
dc.date.accessioned2019-08-30T12:54:14Z
dc.date.available2019-08-30T12:54:14Z
dc.date.issued2009
dc.description.abstractDue to the highly glycolytic metabolism of solid tumours, there is an increased acid production, however, cells are able to maintain physiological pH through plasma membrane efflux of the accumulating protons. Acid efflux through MCTs (monocarboxylate transporters) constitutes one of the most important mechanisms involved in tumour intracellular pH maintenance. Still, the molecular mechanisms underlying the regulation of these proteins are not fully understood. We aimed to evaluate the association between CD147 (MCT1 and MCT4 chaperone) and MCT expression in cervical cancer lesions and the clinico-pathological significance of CD147 expression, alone and in combination with MCTs. The series included 83 biopsy samples of precursor lesions and surgical specimens of 126 invasive carcinomas. Analysis of CD147 expression was performed by immunohistochemistry. CD147 expression was higher in squamous and adenocarcinoma tissues than in the non-neoplastic counterparts and, importantly, both MCT1 and MCT4 were more frequently expressed in CD147 positive cases. Additionally, co-expression of CD147 with MCT1 was associated with lymph-node and/or distant metastases in adenocarcinomas. Our results show a close association between CD147 and MCT1 and MCT4 expressions in human cervical cancer and provided evidence for a prognostic value of CD147 and MCT1 co-expression.pt_BR
dc.identifier.citationPINHEIRO, Celine Pinheiro et al. Monocarboxylate transporters 1 and are associated with CD 147 in cervical carcinoma. Disease Markers, London, v. 26, n. 3, p. 97-103, 2009.pt_BR
dc.identifier.doi10.3233/DMA-2009-0596
dc.identifier.issn0278-0240
dc.identifier.issne- 1875-8630
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18064
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCD147pt_BR
dc.subjectCervical carcinomapt_BR
dc.subjectMonocarboxylate transporterspt_BR
dc.titleMonocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinomapt_BR
dc.typeArtigopt_BR

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