Congenital transmission of Trypanosoma cruzi in central Brazil. A study of 1,211 individuals born to infected mothers
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2015-05
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Resumo
Transmission of Trypanosoma cruzi during pregnancy is estimated to occur in less than 20% of infected moth-
ers; however, the etiopathogenesis is not completely understood. The Centre for Studies on Chagas Disease pro-
vides confirmation of T. cruzi infection for individuals living in central Brazil. In this retrospective hospital-based
study, all requests for diagnosis of T. cruzi infection in individuals less than 21 years old from 1994-2014 were
searched. We end with 1,211 individuals and their respective infected mothers. Congenital transmission of infec-
tion was confirmed in 24 individuals (2%) in central Brazil, an area where the main T. cruzi lineage circulating
in humans is TcII. This low prevalence of congenital Chagas disease is discussed in relation to recent findings in
the south region of Brazil, where TcV is the main lineage and congenital transmission has a higher prevalence
(approximately 5%), similar to frequencies reported in Argentina, Paraguay and Bolivia. This is the first report to
show geographical differences in the rates of congenital transmission of T. cruzi and the relationship between the
prevalence of congenital transmission and the type of Tc prevalent in each region.
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Chagas disease, Familial studies, Trypanosoma cruzi, Geographical differences
Citação
LUQUETTI, Alejandro O. et al. Congenital transmission of Trypanosoma cruzi in central Brazil. A study of 1,211 individuals born to infected mothers. Memorias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 3, p. 369-376, May 2015.