Estudo aberto, multicêntrico de avaliação em médio prazo da eficácia anti-hipertensiva e tolerabilidade da combinação fixa de anlodipino e enalapril no tratamento de pacientes hipertensos primários estágios 1 e 2 – o estudo EMBATES
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Data
2005
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Resumo
To confirm and expand previous observations, in a
multicenter trial named EMBATES we evaluated the
antihypertensive efficacy and tolerability of the fixed
combination of amlodipine and enalapril given to 220
patients with stage 1 and 2 essential hypertension for
16 consecutive weeks, with recording of supine and
standing blood pressure (BP), heart rate and adverse
events every 4 weeks. For 40 patients we also provided
ambulatory blood pressure monitoring (ABPM) before
and at week 16. We observed significant and progressive
reduction of blood pressure that reached values of 134,7
± 14,5/85,8±8,0 mmHg at week 16. Overall anti-hypertensive efficacy rate was 83,4% and 78,7% of the
study population reached normal BP for the criteria of
DBP ≤ 90 mmHg and 51,4% when normal BP criteria
was considered as DBP ≤ 85 mmHg. These rates of
antihypertensive efficacy were independent of patient’s
age and presence or not of diabetes mellitus type 2
associated. ABPM confirm the antihypertensive effect
during the 24 hours and the calculated trough to peak
ratio was 91.3%. Tolerability profile was considered very
good with very low incidence of adverse events that were mainly leg edema, cough and headache in general well
tolerated with very low rate of medication withdrawal. In
conclusion the fixed combination of amlodipine and
enalapril constitute an excellent option for treatment of
broad range of essential hypertensive patients.
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Palavras-chave
Combinação fixa de anti-hipertensivos, Tolerabilidade, Anlodipino, Enalapril, Eficácia anti-hipertensiva, Fixed combination of antihypertensive drugs, Amlodipine, Tolerability, Enalapril, Antihypertensive efficacy
Citação
GOMES, Marco Antonio Mota; JARDIM, Paulo César V. B.; REIS, Altamiro; OIGMAN, Wille; KOHLMANN JR.,Osvaldo. Estudo aberto, multicêntrico de avaliação em médio prazo da eficácia anti-hipertensiva e tolerabilidade da combinação fixa de anlodipino e enalapril no tratamento de pacientes hipertensos primários estágios 1 e 2 - o estudo EMBATES. Revista Brasileira de Hipertensão, São Paulo, v. 12, supl. 1, p. 7-15, 2005.