Genotoxicity and cytotoxicity evaluation of the neolignan analogue 2-(4-nitrophenoxy)-1phenylethanone and its protective effect against DNA damage

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dc.creatorHanusch, Alex Lucas
dc.creatorOliveira, Guilherme Roberto de
dc.creatorSabóia-Morais, Simone Maria Teixeira de
dc.creatorMachado, Rafael Cosme
dc.creatorAnjos, Murilo Machado dos
dc.creatorLee, Chen Chen
dc.date.accessioned2018-08-13T12:11:56Z
dc.date.available2018-08-13T12:11:56Z
dc.date.issued2015-11
dc.description.abstractNeolignans are secondary metabolites found in various groups of Angiosperms. They belong to a class of natural compounds with great diversity of chemical structures and pharmacological activities. These compounds are formed by linking two phenylpropanoid units. Several compounds that have ability to prevent genetic damage have been isolated from plants, and can be used to prevent or delay the development of tumor cells. Genetic toxicology evaluation is widely used in risk assessment of new drugs in preclinical screening tests. In this study, we evaluated the genotoxicity and cytotoxicity of the neolignan analogue 2-(4- nitrophenoxy)-1-phenylethanone (4NF) and its protective effect against DNA damage using the mouse bone marrow micronucleus test and the comet assay in mouse peripheral blood. Our results showed that this neolignan analogue had no genotoxic activity and was able to reduce induced damage both in mouse bone marrow and peripheral blood. Although the neolignan analogue 4NF was cytotoxic, it reduced cyclophosphamide-induced cytotoxicity. In conclusion, it showed no genotoxic action, but exhibited cytotoxic, antigenotoxic, and anticytotoxic activities.pt_BR
dc.identifier.citationHANUSCH, Alex lucas et al. Genotoxicity and cytotoxicity evaluation of the neolignan analogue 2-(4-nitrophenoxy)-1phenylethanone and its protective effect against DNA damage. Plos One, San Francisco, v. 10, n. 11, e0142284, Nov. 2015.pt_BR
dc.identifier.doi10.1371/journal.pone.0142284
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15580
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Química - IQ (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleGenotoxicity and cytotoxicity evaluation of the neolignan analogue 2-(4-nitrophenoxy)-1phenylethanone and its protective effect against DNA damagept_BR
dc.typeArtigopt_BR

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