Genotoxicity and cytotoxicity evaluation of the neolignan analogue 2-(4-nitrophenoxy)-1phenylethanone and its protective effect against DNA damage
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2015-11
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Neolignans are secondary metabolites found in various groups of Angiosperms. They
belong to a class of natural compounds with great diversity of chemical structures and pharmacological
activities. These compounds are formed by linking two phenylpropanoid units.
Several compounds that have ability to prevent genetic damage have been isolated from
plants, and can be used to prevent or delay the development of tumor cells. Genetic toxicology
evaluation is widely used in risk assessment of new drugs in preclinical screening tests.
In this study, we evaluated the genotoxicity and cytotoxicity of the neolignan analogue 2-(4-
nitrophenoxy)-1-phenylethanone (4NF) and its protective effect against DNA damage using
the mouse bone marrow micronucleus test and the comet assay in mouse peripheral blood.
Our results showed that this neolignan analogue had no genotoxic activity and was able to
reduce induced damage both in mouse bone marrow and peripheral blood. Although the
neolignan analogue 4NF was cytotoxic, it reduced cyclophosphamide-induced cytotoxicity.
In conclusion, it showed no genotoxic action, but exhibited cytotoxic, antigenotoxic, and
anticytotoxic activities.
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HANUSCH, Alex lucas et al. Genotoxicity and cytotoxicity evaluation of the neolignan analogue 2-(4-nitrophenoxy)-1phenylethanone and its protective effect against DNA damage. Plos One, San Francisco, v. 10, n. 11, e0142284, Nov. 2015.