Ibopamina 2% vs. sobrecarga hídrica como teste provocativo para glaucoma
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Data
2008
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Resumo
Purpose: To compare the 2% ibopamine provocative test with
the water drinking test as a provocative test for glaucoma.
Methods: Primary open-angle glaucoma patients and normal
individuals were selected from CEROF-Universidade Federal de Goiânia UFG, and underwent the 2% ibopamine provo-
cative test and the water drinking test in a randomized fa-
shion, at least 1 week apart. Intraocular pressure (IOP) be-
fore and after both tests, Bland-Altman graph, sensitivity
and specificity (as mesured by ROC curves) were obtained
for both methods. Results: Forty-seven eyes from 25 pa-
tients were included (27 eyes from 15 glaucoma patients and
20 eyes from 10 normal individuals), with a mean age of 54.2 ±
12.7 years. The mean MD of glaucoma patients was -2.8 ±
2.11 dB. There was no statistically difference in the baseline
IOP (p=0.8) comparing glaucoma patients, but positive after
the provocative tests (p=0.03), and in the IOP variation (4.4 ±
1.3 mmHg for ibopamine and 3.2 ± 2.2 mmHg for water
drinking test, p=0.01). There was no difference in all stu-
died parameters for normal individuals. The Bland-Altman
graph showed high dispersion comparing both methods. The
areas under the ROC curve were 0.987 for the ibopamine
provocative test, and 0.807 for the water-drinking test. Con-
clusion: In this selected subgroup of glaucoma patients
with early visual field defect, the ibopamine provocative
test has shown better sensitivity/specificity than the water
drinking test.
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Palavras-chave
Glaucoma ângulo aberto/diagnóstico, Estudo comparativo, Pressão intra-ocular/efeito de drogas, Sensibilidade e especificidade, Agonistas dopaminérgicos/uso diagnóstico, Testes visuais, Soluções oftálmicas, Técnicas de diagnóstico oftalmológico, Ingestão de líquidos, Água, Glaucoma open-angle/diagnosis, Comparative study, Intraocular pressure/drugs effects, Dopamine agonists/diagnostic use, Diagnostic techniques, ophthalmological, Ophthalmic solutions, Sensibility and specificity, Drinking, Water, Vision tests, Sensibility and specificity
Citação
MAGACHO, Leopoldo et al. Ibopamina 2% vs. sobrecarga hídrica como teste provocativo para glaucoma. Arquivos Brasileiros de Oftalmologia, São Paulo, v. 71, n. 4, p. 499-503, 2008.