Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation

Silva, Danielle Figuerêdo da; Alves, Clayton Queiroz; Brandao, Hugo Neves; David, Jorge Mauricio; David, Juceni Pereira de Lima; Silva, Rangel Leal; Franchin, Marcelo; Cunha, Thiago Mattar; Martins, Felipe Terra; Oliveira, Cecilia Maria Alves de

Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation

Data

2016

Autores

Silva, Danielle Figuerêdo da

Alves, Clayton Queiroz

Brandao, Hugo Neves

David, Jorge Mauricio

David, Juceni Pereira de Lima

Silva, Rangel Leal

Franchin, Marcelo

Cunha, Thiago Mattar

Martins, Felipe Terra

Oliveira, Cecilia Maria Alves de

Resumo

An unusually substituted coumarin, named poligalen, was isolated from a chloroform extract of the aerial parts of Polygala boliviensis. This coumarin was identified by one- and two-dimensional NMR techniques, and the structure of the compound was confirmed by X-ray diffraction. Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. However, poligalen potentiates NF-kB activation.

Citação

SILVA, Danielle F. et al. Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation. Fitoterapia, [s. l.], v. 113, p. 139-143, 2016. DOI: 10.1016/j.fitote.2016.07.021. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0367326X16301794?via%3Dihub. Acesso em: 28 ago. 2023.