Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation

Página do item simplificado
dc.creatorSilva, Danielle Figuerêdo da
dc.creatorAlves, Clayton Queiroz
dc.creatorBrandao, Hugo Neves
dc.creatorDavid, Jorge Mauricio
dc.creatorDavid, Juceni Pereira de Lima
dc.creatorSilva, Rangel Leal
dc.creatorFranchin, Marcelo
dc.creatorCunha, Thiago Mattar
dc.creatorMartins, Felipe Terra
dc.creatorOliveira, Cecilia Maria Alves de
dc.date.accessioned2023-09-06T10:27:47Z
dc.date.available2023-09-06T10:27:47Z
dc.date.issued2016
dc.description.abstractAn unusually substituted coumarin, named poligalen, was isolated from a chloroform extract of the aerial parts of Polygala boliviensis. This coumarin was identified by one- and two-dimensional NMR techniques, and the structure of the compound was confirmed by X-ray diffraction. Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. However, poligalen potentiates NF-kB activation.pt_BR
dc.identifier.citationSILVA, Danielle F. et al. Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation. Fitoterapia, [s. l.], v. 113, p. 139-143, 2016. DOI: 10.1016/j.fitote.2016.07.021. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0367326X16301794?via%3Dihub. Acesso em: 28 ago. 2023.pt_BR
dc.identifier.doi10.1016/j.fitote.2016.07.021
dc.identifier.issne- 1873-6971
dc.identifier.issn0367-326X
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0367326X16301794?via%3Dihub
dc.language.isoengpt_BR
dc.publisher.countryItaliapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.titlePoligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulationpt_BR
dc.typeArtigopt_BR

Arquivos

Licença do Pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IQ - Artigos publicados em periódicos