Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

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dc.creatorZampronha, Rossana de Araújo Catão
dc.creatorFreitas Júnior, Ruffo de
dc.creatorMurta, Eddie Fernando Candido
dc.creatorMichelin, Márcia Antoniazi
dc.creatorD'Alessandro, Aline Almeida Barbaresco
dc.creatorAdad, Sheila Jorge
dc.creatorOliveira, Amaurillo Monteiro de
dc.creatorRassi, Amanda Bruder
dc.creatorOton, Gloria Jabur Bittar
dc.date.accessioned2019-11-01T11:25:53Z
dc.date.available2019-11-01T11:25:53Z
dc.date.issued2013
dc.description.abstractOBJECTIVE: This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis. METHODS: A single-center cohort study was conducted with 86 patients who had undergone radical hysterectomy for stage I cervical cancer. Prognostic factors and the presence of HPV 16 and 18 were analyzed using a polymerase chain reaction assay. A univariate analysis using Kaplan-Meier curves was conducted to estimate survival. RESULTS: The prevalence of HPV 16 in the study group was 65.3%, and the prevalence of HPV 18 was 33.3%. The prevalence of infection with both viruses was 26.9%. Overall survival at 5 years was 91% among women with HPV 18 and 96% among those without this virus type (p = 0.133). Among the women with HPV 16, the overall survival was 94%, whereas this rate was 96% among those without this virus type (p = 0.663). Disease- free survival was unaffected by the presence of HPV type 16 or 18. CONCLUSION: In the present study, despite the high prevalence of HPV types 16 and 18, the presence of these virus types did not affect the prognosis of patients with stage I cervical cancer who underwent radical hysterectomy.pt_BR
dc.identifier.citationZAMPRONHA, Rossana de Araújo Catão et al. Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer. Clinics, São Paulo, v. 68, n. 6, p. 809-814, Jun. 2013.pt_BR
dc.identifier.doi10.6061/clinics/2013(06)14 ISSN 0041-8781
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18304
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHuman Papillomavirus (HPV)pt_BR
dc.subjectSurvivalpt_BR
dc.subjectCervical cancerpt_BR
dc.subjectPrognosispt_BR
dc.titleHuman papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancerpt_BR
dc.typeArtigopt_BR

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