Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer
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Data
2013
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OBJECTIVE: This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in
women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as
well as to establish a correlation between HPV type and cancer prognosis.
METHODS: A single-center cohort study was conducted with 86 patients who had undergone radical
hysterectomy for stage I cervical cancer. Prognostic factors and the presence of HPV 16 and 18 were analyzed
using a polymerase chain reaction assay. A univariate analysis using Kaplan-Meier curves was conducted to
estimate survival.
RESULTS: The prevalence of HPV 16 in the study group was 65.3%, and the prevalence of HPV 18 was 33.3%.
The prevalence of infection with both viruses was 26.9%. Overall survival at 5 years was 91% among women
with HPV 18 and 96% among those without this virus type (p = 0.133). Among the women with HPV 16, the
overall survival was 94%, whereas this rate was 96% among those without this virus type (p = 0.663). Disease-
free survival was unaffected by the presence of HPV type 16 or 18.
CONCLUSION: In the present study, despite the high prevalence of HPV types 16 and 18, the presence of these
virus types did not affect the prognosis of patients with stage I cervical cancer who underwent radical
hysterectomy.
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Human Papillomavirus (HPV), Survival, Cervical cancer, Prognosis
Citação
ZAMPRONHA, Rossana de Araújo Catão et al. Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer. Clinics, São Paulo, v. 68, n. 6, p. 809-814, Jun. 2013.