Ajustes cardiovasculares induzidos pela desidratação crônica nas fases iniciais do período pós-natal em ratos acordados
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Data
2015
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Resumo
Changes in osmolarity of the extracellular compartment may change the volume, metabolism and cellular function. As a result, many
complications can be observed, among them hypertension. Thus, precise regulation of the volume and osmolality of the extracellular
compartment is critical to maintaining normal body functions and survival. Previous results demonstrated that despite anesthetized rats
submitted to chronic diuretic treatment showed no change in sensitivity to sodium and water, an increased arterial pressure was observed. The
present study aims to assess hemodynamic parameters through furosemide-induced dehydration in anaesthetized young rats. Five days old
Wistar rats divided into two groups, a control (n = 10) and a group subjected to subcutaneous treatment with the diuretic Furosemide (10mg/
kg of body weight, n = 12) were used. After treatment, the animals were anesthetized for the implantation of the polyethylene tubes, which were
inserted into the artery (for records cardiovascular variables) and femoral vein through a cut inguinal one side (left / right). The cannulas
were transfixed subcutaneously through the back of the animal and were exteriorized. Data were recorded after a 48h recovery of the surgical
procedure, using an amplifier and software. No differences in induced intake test of water within 120 minutes were observed. With respect to
mean arterial pressure and heart rate, no modification on baseline levels were observed (PAM: 99.4 ± 1.9 mmHg, control vs 102.7 ± 1 mmHg,
furosemide; FC: 362.5 ± 5.2 bpm, control vs 364.9 ± 7 bpm, furosemide). This response pattern was also obtained for SBP (124.3 ± 6 mmHg,
control vs 130 ± 1.6 mmHg, furosemide) and DBP (82.2 ± 1.9 mmHg, control vs 82.1 ± 1 mmHg, furosemide). We concluded that depletion
of the extracellular compartment induced by furosemide administration in young rats is not a determining factor to change the hemodynamic
parameters in adulthood.
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Palavras-chave
Desequilíbrio hidroeletrolítico, Pressão aterial, Concentração osmolar, Desidratação
Citação
LOPES, Paulo Ricardo et al. Ajustes cardiovasculares induzidos pela desidratação crônica nas fases iniciais do período pós-natal em ratos acordados. UNOPAR Científica. Ciências Biológicas e da Saúde, Londrina, v. 17, n. 3, p. 148-153, 2015.