Photodynamic inactivation of Bovine herpesvirus type 1 (BoHV-1) by porphyrins
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2019
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In this work, the photodynamic efficiency of anionic meso-tetrakis sulfonophenyl (TPPS4), cationic meso-tetrakis
methylpyridiniumyl (TMPyP) and their zinc complexes (ZnTPPS4 and ZnTMPyP) in the inactivation of Bovine herpesvirus type
1 (BoHV-1) was evaluated. At a non-cytotoxic concentration, all porphyrins showed significant antiviral activity after
irradiation using a halogen lamp. The efficiency of the cationic porphyrins was higher than that of the anionic ones.
Porphyrin complexation with zinc increases its lipophilicity and the number of absorbed photons, dramatically reducing the
time for complete virus inactivation. The high superposition of the compound optical absorption and light source emission
spectra played a key role in the virus inactivation efficiency. The results demonstrated the high effectivity of the
photodynamic inactivation of BoHV-1. This method can be used as an auxiliary in the treatment of disorders attributed to
BoHV-1 infection, and the porphyrins are promising photosensitizers for this application.
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TELES, Amanda V. et al. Photodynamic inactivation of Bovine herpesvirus type 1 (BoHV-1) by porphyrins. Journal of General Virology, London, v. 99, n. 9, p. 1301-1306, 2018. DOI: 10.1099/jgv.0.001121. Diponível em: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001121#tab2. Acesso em: 12 set. 2023.