Photodynamic inactivation of Bovine herpesvirus type 1 (BoHV-1) by porphyrins

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dc.creatorTeles, Amanda Vargas
dc.creatorOliveira, Taise Maria dos Anjos
dc.creatorBezerra, Fábio de Castro
dc.creatorAlonso, Lais
dc.creatorAlonso, Antonio
dc.creatorBorissevitch, Iouri
dc.creatorGonçalves, Pablo José
dc.creatorSouza, Guilherme Rocha Lino de
dc.date.accessioned2023-11-24T15:46:22Z
dc.date.available2023-11-24T15:46:22Z
dc.date.issued2019
dc.description.abstractIn this work, the photodynamic efficiency of anionic meso-tetrakis sulfonophenyl (TPPS4), cationic meso-tetrakis methylpyridiniumyl (TMPyP) and their zinc complexes (ZnTPPS4 and ZnTMPyP) in the inactivation of Bovine herpesvirus type 1 (BoHV-1) was evaluated. At a non-cytotoxic concentration, all porphyrins showed significant antiviral activity after irradiation using a halogen lamp. The efficiency of the cationic porphyrins was higher than that of the anionic ones. Porphyrin complexation with zinc increases its lipophilicity and the number of absorbed photons, dramatically reducing the time for complete virus inactivation. The high superposition of the compound optical absorption and light source emission spectra played a key role in the virus inactivation efficiency. The results demonstrated the high effectivity of the photodynamic inactivation of BoHV-1. This method can be used as an auxiliary in the treatment of disorders attributed to BoHV-1 infection, and the porphyrins are promising photosensitizers for this application.
dc.identifier.citationTELES, Amanda V. et al. Photodynamic inactivation of Bovine herpesvirus type 1 (BoHV-1) by porphyrins. Journal of General Virology, London, v. 99, n. 9, p. 1301-1306, 2018. DOI: 10.1099/jgv.0.001121. Diponível em: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001121#tab2. Acesso em: 12 set. 2023.
dc.identifier.doi10.1099/jgv.0.001121
dc.identifier.issn0022-1317
dc.identifier.issne- 1465-2099
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/23834
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.publisher.departmentInstituto de Física - IF (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titlePhotodynamic inactivation of Bovine herpesvirus type 1 (BoHV-1) by porphyrins
dc.typeArtigo

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