Influência da suplementação de creatina na capacidade funcional de pacientes com insuficiência cardíaca
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Data
2012
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Resumo
Background: Heart failure (HF) is a complex syndrome characterized by intolerance to exertion and reduced functional capacity.
Objective: To assess the functional capacity of patients with HF and supplemented with creatine.
Methods: Prospective, randomized, double-blind study. Thirty-three male patients over the age of 18 years with functional class II to IV HF were
randomized into two groups as follows: the experimental group (CRE, n = 17), supplemented with 5 g/day of creatine for six months; and the
placebo group (PLA, n = 16), receiving 5 g/day of maltodextrin for that same period. Both groups underwent functional capacity assessment by
use of cardiopulmonary exercise test and 6-minute walk test (6MWT) before and after the intervention. The Ancova statistical model and Pearson
correlation were used to assess the groups and the treatment.
Results: Of the variables assessed on the cardiopulmonary exercise test, peak oxygen consumption (peak VO 2 ), anaerobic threshold (AT), and
oxygen pulse (O 2 pulse) showed no significant differences between the groups (p>0.05). On the 6MWT, no significant difference was observed
in the covered distance.
Conclusion: Creatine supplementation in patients with HF did not significantly improve functional capacity.
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Palavras-chave
Insuficiência cardíaca, Creatina, Suplementação alimentar, Teste de esforço, Heart failure, Exercise test, Creatine, Supplementary feeding
Citação
CARVALHO, Ana Paula Perillo Ferreira et al. Influência da suplementação de creatina na capacidade funcional de pacientes com insuficiência cardíaca. Arquivos Brasileiros de Cardiologia, São Paulo, v. 99, n. 1, p. 623-629, 2012.