Tubular urinary enzymes in acute post-infectious glomerulonephritis
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Data
2001
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Resumo
Tubular function of 17 pediatric patients with
a mild form of acute post-infectious glomerulonephritis
was prospectively evaluated by assessment of the urinary
activity of proximal and distal tubule enzymes. Neutrallike
endopeptidase (NEP-like) and angiotensin-converting
enzyme (ACE) were the proximal tubule enzymes
assessed, while prolyl-endopeptidase (PE) and serine-endopeptidase
H1 and H2 were the distal tubule enzymes
analyzed. Urine was collected at diagnosis (T0) and
after 2 (T2) and 6 (T6) months of follow-up. NEP-like
enzyme activity (nmol/mg creatinine; median±quartile
range) was increased at diagnosis, and this remained
stable during the first 6 months (T0 18.30±83.26, T2
17.32±49.56, T6 23.38±107.18). Urinary activity of the
other enzymes was as follows: ACE (mU/ml per mg
creatinine) T0 0.08±0.16, T2 0.06±0.10, T6 0.18±0.29;
PE (nmol/mg creatinine) T0 6.70±84.87, T2 9.55±69.00,
T6 13.67±28.70; serine-endopeptidase H1 (nmol/mg creatinine)
T0 7.86±26.95, T2 17.17±59.37, T6 18.19±
79.14; and serine-thiol-endopeptidase H2 (nmol/mg creatinine)
T0 3.06±21.97, T2 12.06±32.42, T6 16.22±
44.06. Thirty other healthy children matched for age and
gender were considered as a control group. This group
was assessed once and the results were: NEP-like
activity 6.05±10.54, ACE 0.11±0.22, PE 7.10±13.36, H1
5.00±17.30, and H2 6.00±20.16. In conclusion, we observed
that NEP-like and H1 enzymes exhibited significant
increased urinary activity 6 months after the diagnosis.
This increase occurred in spite of the disappearance
of clinical symptoms, which occurred 2 months after the
diagnosis. We believe that the increase in urinary enzymatic
activity could be a manifestation of a silent tubular
dysfunction following an episode of acute post-infectious
glomerulonephritis.
Descrição
Palavras-chave
Glomerulonephritis, Renal tubular function, Acute disease, Peptide hydrolases, Endopeptidases
Citação
NAGHETTINI, Alessandra Vitorino et al. Tubular urinary enzymes in acute post-infectious glomerulonephritis. Pediatric Nephrology, Berlin, v. 16, n. 9, p. 719-722, 2001.