Tubular urinary enzymes in acute post-infectious glomerulonephritis

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dc.creatorNaghettini, Alessandra Vitorino
dc.creatorNogueira, Paulo Cesar Koch
dc.creatorJuliano, Maria Ligia
dc.creatorBueno, Allain Amador
dc.creatorCasarini, Dulce Elena
dc.creatorCarvalhães, João Tomás de Abreu
dc.date.accessioned2022-07-08T12:28:49Z
dc.date.available2022-07-08T12:28:49Z
dc.date.issued2001
dc.description.abstractTubular function of 17 pediatric patients with a mild form of acute post-infectious glomerulonephritis was prospectively evaluated by assessment of the urinary activity of proximal and distal tubule enzymes. Neutrallike endopeptidase (NEP-like) and angiotensin-converting enzyme (ACE) were the proximal tubule enzymes assessed, while prolyl-endopeptidase (PE) and serine-endopeptidase H1 and H2 were the distal tubule enzymes analyzed. Urine was collected at diagnosis (T0) and after 2 (T2) and 6 (T6) months of follow-up. NEP-like enzyme activity (nmol/mg creatinine; median±quartile range) was increased at diagnosis, and this remained stable during the first 6 months (T0 18.30±83.26, T2 17.32±49.56, T6 23.38±107.18). Urinary activity of the other enzymes was as follows: ACE (mU/ml per mg creatinine) T0 0.08±0.16, T2 0.06±0.10, T6 0.18±0.29; PE (nmol/mg creatinine) T0 6.70±84.87, T2 9.55±69.00, T6 13.67±28.70; serine-endopeptidase H1 (nmol/mg creatinine) T0 7.86±26.95, T2 17.17±59.37, T6 18.19± 79.14; and serine-thiol-endopeptidase H2 (nmol/mg creatinine) T0 3.06±21.97, T2 12.06±32.42, T6 16.22± 44.06. Thirty other healthy children matched for age and gender were considered as a control group. This group was assessed once and the results were: NEP-like activity 6.05±10.54, ACE 0.11±0.22, PE 7.10±13.36, H1 5.00±17.30, and H2 6.00±20.16. In conclusion, we observed that NEP-like and H1 enzymes exhibited significant increased urinary activity 6 months after the diagnosis. This increase occurred in spite of the disappearance of clinical symptoms, which occurred 2 months after the diagnosis. We believe that the increase in urinary enzymatic activity could be a manifestation of a silent tubular dysfunction following an episode of acute post-infectious glomerulonephritis.pt_BR
dc.identifier.citationNAGHETTINI, Alessandra Vitorino et al. Tubular urinary enzymes in acute post-infectious glomerulonephritis. Pediatric Nephrology, Berlin, v. 16, n. 9, p. 719-722, 2001.pt_BR
dc.identifier.doi10.1007/s004670100643
dc.identifier.issne- 1432-198X
dc.identifier.issn0931-041X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/20932
dc.language.isoengpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGlomerulonephritispt_BR
dc.subjectRenal tubular functionpt_BR
dc.subjectAcute diseasept_BR
dc.subjectPeptide hydrolasespt_BR
dc.subjectEndopeptidasespt_BR
dc.titleTubular urinary enzymes in acute post-infectious glomerulonephritispt_BR
dc.typeArtigopt_BR

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