Preparation and characterization of solid oral dosage forms containing soy isoflavones
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Data
2013-02
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Resumo
Soy isoflavones have been extensively used for menopausal symptoms
and prevention of hormone-related cancer, osteoporosis and cardiovascular diseases.
Commercially available forms of isoflavones include supplements, capsules and
tablets. However, the non-standardization of soy isoflavones extracts and different
dissolution profiles of these solid dosage forms highlight the need of additional
studies on the development of well characterized pharmaceutical dosage forms of
isoflavones. In this work, immediate release oral tablets of soy isoflavones were
obtained and evaluated. Genistein and daidzein, were the main constituents of the
dried soy extract. Preparation of the tables was accomplished in a rotary tableting
machine following either a dry mixture for direct compression or wet granulation
with different excipients. Powder, granules and tablets were evaluated for several
parameters, including flow properties, Carr and Hausner indexes, hardness, friability,
disintegration time and drug release profile. Also, a fast and validated HPLC
analytical method for both genistein and daidzein was developed. Formulations
containing sodium croscarmellose and sodium dodecyl sulfate resulted in better
flowability as indicated by the flow rate and angle of repose, faster disintegration
time and immediate release dissolution profile.
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Palavras-chave
Daidzein, Isoflavone extract, Dissolution, Tablet, Genistein, HPLC
Citação
OLIVEIRA, Stela R. et al. Preparation and characterization of solid oral dosage forms containing soy isoflavones. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 1, p. 175-181, Jan./Feb. 2013.