Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice
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2013-09
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Resumo
The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its
indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was
to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acariçoba’s
underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic
acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic
activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration
and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema
induced by carrageenan until the second hour and also the edema induced by dextran. In conclusion our
results showed that EEA of H. umbellata L. presents analgesic and anti-inflammatory activities, and that
a blockade of activity or reduction in the release of different mediators, such as histamine and serotonin,
could be involved in these pharmacologic effects.
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Acariçoba, Hydrocotyle umbellata L., Anti-inflammatory, Biomedical sciences, Antinociceptive
Citação
FLORENTINO, Iziara F. et al. Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 85, n. 3, p. 987-997, Sept. 2013.