HPV infection and cervical neoplasia: associated risk factors
Carregando...
Data
2015
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Background: Behavioral risks such as age at first sexual intercourse, number of sexual partners and partner’s sexual
behavior are associated with an increased risk of HPV infection, persistence of the infection and the development
of neoplastic precursor lesions. The objective of this study was to evaluate the risk factors associated with HPV
positivity and with a diagnosis of cervical neoplasia in women referred with an abnormal cervical smear.
Methods: This study evaluated a series of 198 women referred with an abnormal cervical smear. Risk factors for
HPV infection were investigated using a questionnaire. All cervical specimens were tested for 27 HPV genotypes
using the Roche polymerase chain reaction reverse line blot assay.
Results: The overall prevalence of HPV was 87 %. First sexual intercourse before 16 years of age was significantly
associated with a positive HPV test (OR 4.41; 95 %CI: 1.20 − 19.33; p = 0.01). A significant association was also found
between this risk factor and CIN 1 lesions or worse (OR 2.2; 95 %CI 0.94 − 5.08; p = 0.03).
Conclusions: The age at which a woman begins to be sexually active is associated with HPV infection and with a
diagnosis of cervical neoplasia.
Descrição
Palavras-chave
Human papillomavirus, Risk factors, Abnormal cervical smear
Citação
RIBEIRO, Andrea Alves et al. HPV infection and cervical neoplasia: associated risk factors. Infectious Agents and Cancer, New York, v. 10, n. 16, p. 1-8, 2015.