Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian population

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dc.creatorMesquita, Wyara Elanne de Jesus Castro
dc.creatorApprobato, Mário Silva
dc.creatorMoura, Kátia Karina Verolli de Oliveira
dc.creatorJesuíno, Rosália Santos Amorim
dc.date.accessioned2019-08-20T15:18:05Z
dc.date.available2019-08-20T15:18:05Z
dc.date.issued2009
dc.description.abstractThe androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligozoospermic (N = 31), asthenozoospermic (N = 23), teratozoospermic (N = 33), and azoospermic (N = 24) men were analyzed. The extracted DNA was amplified for the exon 1 region of the AR gene. There was a significant correlation between the ab- sence of exon 1 in the AR gene and spermatogenesis defects (P = 0.015). This association was significant in teratozoospermic men (51.5% of the sample). We found that lack of amplification of exon 1 of the AR gene by polymerase chain reaction is associated with morphological defects in the spermogram.pt_BR
dc.identifier.citationMESQUITA, W. E. J. C.; APPROBATO, M. S.; MOURA, K. K. V. O.; JESUINO, R. S. A. Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian population. Genetics and Molecular Research, Ribeirão Preto, v. 8, n. 4, p. 1423-1426, Nov. 2009.pt_BR
dc.identifier.issn1676-5680
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/17951
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAndrogen receptorpt_BR
dc.subjectTeratozoospermiapt_BR
dc.subjectAR genept_BR
dc.subjectSpermatogenesispt_BR
dc.subjectMale infertilitypt_BR
dc.titleAbsence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian populationpt_BR
dc.typeArtigopt_BR

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