Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian population
dc.creator | Mesquita, Wyara Elanne de Jesus Castro | |
dc.creator | Approbato, Mário Silva | |
dc.creator | Moura, Kátia Karina Verolli de Oliveira | |
dc.creator | Jesuíno, Rosália Santos Amorim | |
dc.date.accessioned | 2019-08-20T15:18:05Z | |
dc.date.available | 2019-08-20T15:18:05Z | |
dc.date.issued | 2009 | |
dc.description.abstract | The androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligozoospermic (N = 31), asthenozoospermic (N = 23), teratozoospermic (N = 33), and azoospermic (N = 24) men were analyzed. The extracted DNA was amplified for the exon 1 region of the AR gene. There was a significant correlation between the ab- sence of exon 1 in the AR gene and spermatogenesis defects (P = 0.015). This association was significant in teratozoospermic men (51.5% of the sample). We found that lack of amplification of exon 1 of the AR gene by polymerase chain reaction is associated with morphological defects in the spermogram. | pt_BR |
dc.identifier.citation | MESQUITA, W. E. J. C.; APPROBATO, M. S.; MOURA, K. K. V. O.; JESUINO, R. S. A. Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian population. Genetics and Molecular Research, Ribeirão Preto, v. 8, n. 4, p. 1423-1426, Nov. 2009. | pt_BR |
dc.identifier.issn | 1676-5680 | |
dc.identifier.uri | http://repositorio.bc.ufg.br/handle/ri/17951 | |
dc.language.iso | eng | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | Faculdade de Medicina - FM (RG) | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | Androgen receptor | pt_BR |
dc.subject | Teratozoospermia | pt_BR |
dc.subject | AR gene | pt_BR |
dc.subject | Spermatogenesis | pt_BR |
dc.subject | Male infertility | pt_BR |
dc.title | Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian population | pt_BR |
dc.type | Artigo | pt_BR |
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