Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian population
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Data
2009
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Resumo
The androgen receptor (AR) is a protein encoded by
the AR gene, which when mutated may affect spermatogenesis, the
process in which spermatozoa are produced; thus, AR mutations
could lead to male infertility. We examined exon 1 of the AR gene
in men with idiopathic infertility. Blood or semen samples from 111
infertile, oligozoospermic (N = 31), asthenozoospermic (N = 23),
teratozoospermic (N = 33), and azoospermic (N = 24) men were
analyzed. The extracted DNA was amplified for the exon 1 region
of the AR gene. There was a significant correlation between the ab-
sence of exon 1 in the AR gene and spermatogenesis defects (P =
0.015). This association was significant in teratozoospermic men
(51.5% of the sample). We found that lack of amplification of exon 1 of the AR gene by polymerase chain reaction is associated with
morphological defects in the spermogram.
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Palavras-chave
Androgen receptor, Teratozoospermia, AR gene, Spermatogenesis, Male infertility
Citação
MESQUITA, W. E. J. C.; APPROBATO, M. S.; MOURA, K. K. V. O.; JESUINO, R. S. A. Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian population. Genetics and Molecular Research, Ribeirão Preto, v. 8, n. 4, p. 1423-1426, Nov. 2009.