Ausência de mutagenicidade de Solanum paniculatum L. em células somáticas de Drosophila melanogaster: SMART/asa
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Data
2009
Título da Revista
ISSN da Revista
Título de Volume
Editor
Vera Lúcia Gomes Klein
Resumo
The lyophilized aqueous extract of Solanum paniculatum L. (jurubeba) leaves, a medicinal plant
widely used by people as diuretic, in liver and spleen treatments, against fever and inflammation, underwent
the SMART/wing test in somatic cells of Drosophila melanogaster for the evaluation of its mutagenic potential.
We used three different concentrations of the leaf extract (2.5 mg.mL-1, 6.25 mg.mL-1, and 10 mg.mL-1),
doxorubicin (DXR) as positive control, and distilled water with 5% sucrose as negative control. We
employed three lineages of Drosophila in this experiment, flr³, ORR, and mwh. The larvae derived from
the standard cross (ST: flr³ females x mwh males) and the high bioactivation cross (HB: ORR females x
mwh males) were chronically treated and the wings of the emerging adults were analyzed. Our results
showed no mutagenic activity of S. paniculatum L. ST or HB crosses.
Descrição
v. 6, n. 2, p. 27-33, 2009.
Palavras-chave
Drosophila melanogaster, Genotoxicidade, Jurubeba, SMART/asa, Solanum paniculatum L.
Citação
RIBEIRO, Vivian; VIEIRA, Iara Lúcia Barbosa Fernandes; PASSOS, Débora Cristina Silva dos; SILVA, Elayne Miguel da; VALE, Camila Regina do; FELÍCIO, Leandro Prado; FERREIRA, Heleno Dias; VIEIRA, Pabline Marinho; CARVALHO, Salvador de. Ausência de mutagenicidade de Solanum paniculatum L. em células somáticas de Drosophila melanogaster: SMART/asa. Revista de Biologia Neotropical, v. 6, n. 2, p. 27-33, 2009. Disponível em: <http://www.revistas.ufg.br/index.php/RBN/article/view/12851/8439>.