Desenvolvimento e validação de metodologia analítica espectrofotométrica para doseamento de mebendazol matéria-prima e suspensão oral

Resumo

The mebendazole is a drug that acts as anti-helminthic of broad spectrum of action against nematodes and cestodes. Among the methodologies used for their determination, highlights the possibility for quantitative determination of mebendazole is through methods spectrophotometrics, to have good sensitivity and have cost more accessible. This study aimed to develop and validate a method for analytical determination of mebendazole in raw material and in oral suspension, using the ultraviolet spectrophotometry. The method proved to be simple, rapid, specific, linear, accurate, precise and robust to run the routine of a laboratory of quality control, and is an alternative to methods used.

Descrição

Palavras-chave

Controle de qualidade, Análise farmacêutica, Espectrofotometria, Quality control, Pharmaceutical analysis, Spectrophotometry

Citação

SILVA, Ezequiane Machadom; DUARTE, Lívia Teixeira; SOUSA, Andrezza Lopes; MARTINS, Daniella Ramos; ALMEIDA, Larissa da Cunha; PEREIRA, Paula Izabella Rocha de Magalhães; GARROTE, Clévia Ferreira Duarte; BARA, Maria Teresa Freitas. Desenvolvimento e validação de metodologia analítica espectrofotométrica para doseamento de mebendazol matéria-prima e suspensão oral. Revista Eletrônica de Farmácia, Goiânia, v. 6, n. 1, p. 25-326, jan./mar. 2009. Disponível em: <https://revistas.ufg.br/REF/article/view/5858/4558>.