Modulation of fibronectin and laminin expression by Rhodium (II) citrate-coated maghemite nanoparticles in mice bearing breast tumor

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dc.creatorRocha, Márcia Cristina Oliveira da
dc.creatorArcanjo, Rachel Braz
dc.creatorLopes, Cláudio Afonso Pinho
dc.creatorCarneiro, Marcella Lemos Brettas
dc.creatorSouza, Aparecido Ribeiro de
dc.date.accessioned2023-06-26T12:08:41Z
dc.date.available2023-06-26T12:08:41Z
dc.date.issued2017-12-20
dc.description.abstractDegradation of cellular matrix is one of the important processes related to the progression of breast cancer. Tumor cells have the ability to exhibit necessary conditions for growth and survival, promoting degradation processes of extracellular matrix proteins, such as laminin (LN) and fibronectin (FN). In this study, we evaluated whether treatments, based on free rhodium (II) citrate (Rh2(H2cit)4), maghemite nanoparticles coated with citrate (Magh-cit) and maghemite nanoparticles coated with rhodium (II) citrate (Magh-Rh2(H2cit)4), in murine metastatic breast carcinoma models can modulate the expression of laminin and fibronectin proteins. Synthesized nanoparticles were characterized using X-ray diffraction, transmission electron microscopy, energy dispersive spectroscopy and dynamic light scattering. The expression of FN and LN was assessed using immunohistochemistry and western blotting. The gene expression of FN1 and LAMA1 were evaluated using real-time PCR. The FN1 and LAMA1 transcripts from the Magh-Rh2(H2cit)4 treated group were 95% and 94%, respectively, lower than the control group. Significant reduction in tumor volume for animals treated with Magh-Rh2(H2cit)4 was observed, of about 83%. We witnessed statistically significant reductions of FN and LN expression following treatment with Magh-Rh2(H2cit)4. We have demonstrated that the antitumor effects of Magh- Rh2(H2cit)4 and Rh2(H2cit)4 regulate the expression of FN and LN in metastatic breast tumors.pt_BR
dc.identifier.citationROCHA, Márcia et al. Modulation of fibronectin and laminin expression by Rhodium (II) citrate-coated maghemite nanoparticles in mice bearing breast tumor. Scientific Reports, London, v. 7, e17904, 2017. DOI: 10.1038/s41598-017-18204-1. Disponível em: https://www.nature.com/articles/s41598-017-18204-1. Acesso em: 16 jun. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-017-18204-1
dc.identifier.issne- 2045-2322
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/22757
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleModulation of fibronectin and laminin expression by Rhodium (II) citrate-coated maghemite nanoparticles in mice bearing breast tumorpt_BR
dc.typeArtigopt_BR

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