Avaliação da toxicidade aguda do extrato aquoso de Apeiba tibourbou Aubl (Tiliaceae), em camundongos e ratos
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Data
2013
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Resumo
The acute toxicity test estimates the median lethal dose (LD50) against a given test organism and classifies toxic substances, including plant extracts, according to their intrinsic toxicity. Apeiba tibourbou Aubl (Tiliaceae), a tree known in Brazil as “raft-wood” or “monkey’s comb”, is popularly used as an antirheumatic, antispasmodic and expectorant agent, although its toxic effects are unknown. The objective of this research was therefore to investigate the potential acute toxicity to female mice and rats of a water extract of A. tibourbou leaves (WET), administered by gavage, following OECD Guideline 423/2001 and hippocratic screening. The female mice were divided into three groups of three animals each (C1 – control, given 0.25 mL filtered water; C2 – treated with 300 mg/kg WET; C3 – with 2000 mg/kg WET). The female rats were divided into two groups of three animals each (R1 – control, given 0.5 mL filtered water; R2 – 2000 mg/kg WET). Group C2 consumed 28% more water than group C1 (p < 0.05); group C3 produced 31% more excreta than group C1 (p < 0.0001); group R2 reduced food consumption and excretion by 20% and 28%, relative to group R1 (p < 0.05), respectively. During the Hippocratic screening, no motor and/or sensorial alterations were observed. Neither death nor symptoms of impending death were observed in any animals. It can be concluded that WET has an estimated LD50 greater than 2000 mg/kg (Class 5 toxicity, according to the UN Globally Harmonized System – GHS), demonstrating low acute toxicity potential.
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Toxicidade aguda, Screening hipocrático, Apeiba tibourbou, Acute toxicity, Apeiba tibourbou, Hippocratic screening
Citação
CUNHA, Luiz Carlos da et al. Avaliação da toxicidade aguda do extrato aquoso de Apeiba tibourbou Aubl (Tiliaceae), em camundongos e ratos. Revista de Ciências Farmacêuticas Básica e Aplicada, Araraquara, v. 34, n. 3, p. 357-362, 2013.