Antimicrobial activity of the crude ethanol extract from Pimenta pseudocaryophyllus
Data
2009
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Resumo
The antimicrobial activity of the crude ethanol extract from Pimenta pseudocaryophyllus (Gomes)
L. R. Landrum (Myrtaceae), collected at two locations in Brazil, was investigated. Leaf samples were collected
in April 2005 and in September 2005, both in Brasília, DF, Brazil, and in July 2000 in São Gonçalo do
Abaeté, MG, Brazil. They were dried, crushed and used to obtain three crude ethanol extracts. The agar
diffusion test was used for antimicrobial activity screening and the agar dilution method for determining
the minimal inhibitory concentration (MIC). In assay conditions, extracts I, II and III demonstrated antimicrobial
activity against Gram-positive Staphylococcus aureus, Micrococcus luteus, M. roseus, Bacillus cereus,
B. atrophaeus, and B. stearothermophilus (MIC 0.39062 to 12.5 mg/mL, MIC 0.78125 to 1.5625 mg/mL and
MIC 0.39062 to 1.5625 mg/mL, respectively), against Gram-negative Pseudomonas aeruginosa (MIC 0.39062
to 3.125 mg/mL, MIC 1.5625 mg/mL and MIC 0.78125 to 1.5625 mg/mL, respectively), against clinical isolates
of Pseudomonas stutzeri (MIC 0.39062 to 0.78125 mg/mL, MIC 0.78125 to 1.5625 mg/mL, MIC 0.78125
to 1.5625 mg/mL, respectively) and also against Candida albicans fungi (MIC 0.19531 mg/mL for the extracts
I, II and III). This study showed that the antimicrobial activity of P. pseudocaryophyllus might be considered
sufficient to encourage further studies to isolate and identify its active principles. Pharmacological and
toxicological studies are also necessary, followed by studies regarding the culturing and managing processes
of this vegetable.
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Palavras-chave
Agar diffusion test, Fungi, Agar dilution method, Minimal inhibitory concentration, Bacteria
Citação
PAULA, Joelma Abadia Marciano de; PAULA, José Realino de; PIMENTA, Fabiana Cristina; REZENDE, Maria Helena; BARA, Maria Teresa Freitas. Antimicrobial activity of the crude ethanol extract from Pimenta pseudocaryophyllus. Pharmaceutical Biology, New York, v. 47, n. 10, p. 987-993, 2009.