Integrated metabolic and inflammatory signatures associated with severity of, fatality of, and recovery from COVID-19
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2023-04
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Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the
pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can
be explored to identify correlates of protection. The cellular metabolism represents a
potential target to improve survival upon severe disease, but the associations between
the metabolism and the inflammatory response during COVID-19 are not well defined.
We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of
20 individuals was followed up after hospital discharge and recovery from acute disease.
We used hierarchical community networks to integrate metabolomics profiles with cytokines and markers of inflammation, coagulation, and tissue damage. Infection by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes significant alterations
in the plasma metabolome, whose activity varies according to disease severity and correlates with oxygen saturation. Differential metabolism underlying death was marked by
amino acids and related metabolites, such as glutamate, glutamyl-glutamate, and oxoproline, and lipids, including progesterone, phosphocholine, and lysophosphatidylcholines
(lysoPCs). Individuals who recovered from severe disease displayed persistent alterations
enriched for metabolism of purines and phosphatidylinositol phosphate and glycolysis.
Recovery of mild disease was associated with vitamin E metabolism. Data integration
shows that the metabolic response is a hub connecting other biological features during
disease and recovery. Infection by SARS-CoV-2 induces concerted activity of metabolic and
inflammatory responses that depend on disease severity and collectively predict clinical
outcomes of COVID-19.
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COVID-19, Data integration, Inflammation, Metabolomics
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GARDINASSI, Luiz Gustavo et al. Integrated metabolic and inflammatory signatures associated with severity of, fatality of, and recovery from COVID-19. Microbiology Spectrum, Atlanta, v. 11, n. 2, Mar./Apr. 2023. DOI: 10.1128/spectrum.02194-22. Disponível em: https://journals.asm.org/doi/10.1128/spectrum.02194-22. Acesso em: 17 maio 2023.