Integrated metabolic and inflammatory signatures associated with severity of, fatality of, and recovery from COVID-19

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dc.creatorGardinassi, Luiz Gustavo Araujo
dc.creatorServian, Carolina do Prado
dc.creatorLima, Gesiane da Silva
dc.creatorAnjos, Déborah Carolina Carvalho dos
dc.creatorGomes Junior, Antonio Roberto
dc.creatorGuilarde, Adriana Oliveira
dc.creatorBorges, Moara Alves Santa Bárbara
dc.creatorSantos, Gabriel Franco dos
dc.creatorMoraes, Brenda Grazielli Nogueira
dc.creatorSilva, João Marcos Maia
dc.creatorChaves, Andréa Rodrigues
dc.date.accessioned2023-05-30T15:22:43Z
dc.date.available2023-05-30T15:22:43Z
dc.date.issued2023-04
dc.description.abstractSevere manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can be explored to identify correlates of protection. The cellular metabolism represents a potential target to improve survival upon severe disease, but the associations between the metabolism and the inflammatory response during COVID-19 are not well defined. We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of 20 individuals was followed up after hospital discharge and recovery from acute disease. We used hierarchical community networks to integrate metabolomics profiles with cytokines and markers of inflammation, coagulation, and tissue damage. Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes significant alterations in the plasma metabolome, whose activity varies according to disease severity and correlates with oxygen saturation. Differential metabolism underlying death was marked by amino acids and related metabolites, such as glutamate, glutamyl-glutamate, and oxoproline, and lipids, including progesterone, phosphocholine, and lysophosphatidylcholines (lysoPCs). Individuals who recovered from severe disease displayed persistent alterations enriched for metabolism of purines and phosphatidylinositol phosphate and glycolysis. Recovery of mild disease was associated with vitamin E metabolism. Data integration shows that the metabolic response is a hub connecting other biological features during disease and recovery. Infection by SARS-CoV-2 induces concerted activity of metabolic and inflammatory responses that depend on disease severity and collectively predict clinical outcomes of COVID-19.pt_BR
dc.identifier.citationGARDINASSI, Luiz Gustavo et al. Integrated metabolic and inflammatory signatures associated with severity of, fatality of, and recovery from COVID-19. Microbiology Spectrum, Atlanta, v. 11, n. 2, Mar./Apr. 2023. DOI: 10.1128/spectrum.02194-22. Disponível em: https://journals.asm.org/doi/10.1128/spectrum.02194-22. Acesso em: 17 maio 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1128/spectrum.02194-22
dc.identifier.issne- 2165-0497
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/22636
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCOVID-19pt_BR
dc.subjectData integrationpt_BR
dc.subjectInflammationpt_BR
dc.subjectMetabolomicspt_BR
dc.titleIntegrated metabolic and inflammatory signatures associated with severity of, fatality of, and recovery from COVID-19pt_BR
dc.typeArtigopt_BR

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