Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes
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2020
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Resumo
The Hancornia speciosa latex reveals angiogenic, osteogenic, and anti inflammatory properties, which present its potential for developing of wound healing
drugs; however, the latex compounds responsible for angiogenesis remain unknown.
One strategy to screen these active compounds is evaluation of latex fractions. This study
aimed to obtain different fractions of latex and evaluate its angiogenic activity separately
using the chick chorioallantoic membrane (CAM) assay. The serum (SE) fraction was
responsible for angiogenesis, which was subject to biochemical characterization and
computational simulations in order to understand the contribution of H. speciosa latex
in wound healing process. Our results revealed weak antioxidant potential and absence
of antimicrobial activity in the SE fraction. Phytochemical analysis identified chlorogenic
acids (CGA) as the main compound of SE fraction. CGA bioactivity predictions identify
different molecules associated with extracellular matrix (ECM) remodeling, such as
metalloproteinases, which also are overexpressed in our CAM assay experiment. Docking
simulations revealed the interactions between CGA and matrix metalloproteinase 2. In
conclusion, SE latex fraction stimulates angiogenesis and may influence ECM remodeling.
These properties may contribute to the wound healing process, and also confirm the
widespread use of this plant.
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Chlorogenic acid, Secondary metabolites, Chronic wounds, Docking simulations, Mangabeira
Citação
D’ABADIA, Patrícia L. et al. Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 92, n. 2, e20190107, 2020. DOI: 10.1590/0001-3765202020190107. Disponível em: https://www.scielo.br/j/aabc/a/jGrQxq4gDdMDbDSKkwnB7yD/?format=pdf&lang=en. Acesso em: 5 maio 2023.