Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes

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dc.creatorD'Abadia, Patrícia Lima
dc.creatorBailão, Elisa Flávia Luiz Cardoso
dc.creatorLino Junior, Ruy de Souza
dc.creatorOliveira, Matheus Gabriel de
dc.creatorSilva, Vinicius Barreto da
dc.creatorOliveira, Leandra de Almeida Ribeiro
dc.creatorConceição, Edemilson Cardoso da
dc.creatorReis, Paulo Roberto de Melo
dc.creatorBorges, Leonardo Luiz
dc.creatorGonçalves, Pablo José
dc.creatorAlmeida, Luciane Madureira de
dc.date.accessioned2023-05-10T14:04:34Z
dc.date.available2023-05-10T14:04:34Z
dc.date.issued2020
dc.description.abstractThe Hancornia speciosa latex reveals angiogenic, osteogenic, and anti inflammatory properties, which present its potential for developing of wound healing drugs; however, the latex compounds responsible for angiogenesis remain unknown. One strategy to screen these active compounds is evaluation of latex fractions. This study aimed to obtain different fractions of latex and evaluate its angiogenic activity separately using the chick chorioallantoic membrane (CAM) assay. The serum (SE) fraction was responsible for angiogenesis, which was subject to biochemical characterization and computational simulations in order to understand the contribution of H. speciosa latex in wound healing process. Our results revealed weak antioxidant potential and absence of antimicrobial activity in the SE fraction. Phytochemical analysis identified chlorogenic acids (CGA) as the main compound of SE fraction. CGA bioactivity predictions identify different molecules associated with extracellular matrix (ECM) remodeling, such as metalloproteinases, which also are overexpressed in our CAM assay experiment. Docking simulations revealed the interactions between CGA and matrix metalloproteinase 2. In conclusion, SE latex fraction stimulates angiogenesis and may influence ECM remodeling. These properties may contribute to the wound healing process, and also confirm the widespread use of this plant.pt_BR
dc.identifier.citationD’ABADIA, Patrícia L. et al. Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 92, n. 2, e20190107, 2020. DOI: 10.1590/0001-3765202020190107. Disponível em: https://www.scielo.br/j/aabc/a/jGrQxq4gDdMDbDSKkwnB7yD/?format=pdf&lang=en. Acesso em: 5 maio 2023.pt_BR
dc.identifier.doi10.1590/0001-3765202020190107
dc.identifier.issn0001-3765
dc.identifier.issne- 1678-2690
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/22498
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Física - IF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChlorogenic acidpt_BR
dc.subjectSecondary metabolitespt_BR
dc.subjectChronic woundspt_BR
dc.subjectDocking simulationspt_BR
dc.subjectMangabeirapt_BR
dc.titleHancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processespt_BR
dc.typeArtigopt_BR

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