Microemulsion based on Pterodon emarginatus oil and its anti‑inflammatory potential

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dc.creatorPascoa, Henrique
dc.creatorDiniz, Danielle Guimarães Almeida
dc.creatorFlorentino, Iziara Ferreira
dc.creatorCosta, Elson Alves
dc.creatorBara, Maria Teresa Freitas
dc.date.accessioned2022-05-30T15:53:45Z
dc.date.available2022-05-30T15:53:45Z
dc.date.issued2015-03
dc.description.abstracta Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus (“sucupira”) oil was evaluated and the anti-inflammatory potential of this microemulsion was also examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor Oil (Ultramone® R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of 10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity index, on the 1st, 7th, 15th, and 30th days after preparation and stored at different temperatures (5 ± 2 °C, 25 ± 2 °C, and 40 ± 2 °C). The anti-inflammatory in vivo activity of both oil and formulation were evaluated, using the experimental model of croton oil-induced ear edema. The preliminary stability test showed that the microemulsion stored at 5 and 25 °C retained its original features throughout the 30- day period. The anti-inflammatory potential of both oil and formulation was shown to be statistically significant (p < 0.001), when compared to the control group, however, the microemulsion proved to be more effective (p < 0.05) than the oil when applied directly to the ear.pt_BR
dc.identifier.citationPASCOA, Henrique; DINIZ, Danielle Guimarães Almeida; FLORENTINO, Iziara Ferreira ; COSTA, Elson Alves; BARA, Maria Teresa Freitas. Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 51, n. 1, p. 117-125, Jan./Mar. 2015.pt_BR
dc.identifier.issne- 2175-9790
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/20807
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Farmácia - FF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPterodon emarginatus/pharmacognosypt_BR
dc.subjectPterodon emarginatus/óleo/atividade anti inflamatóriapt_BR
dc.subjectTecnologia farmacêuticapt_BR
dc.subjectMicroemulsãopt_BR
dc.subjectFitoterápicopt_BR
dc.subjectPlantas medicinaispt_BR
dc.titleMicroemulsion based on Pterodon emarginatus oil and its anti‑inflammatory potentialpt_BR
dc.typeArtigopt_BR

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