Microemulsion based on Pterodon emarginatus oil and its anti‑inflammatory potential
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Data
2015-03
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Resumo
a Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus
(“sucupira”) oil was evaluated and the anti-inflammatory potential of this microemulsion was also
examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor
Oil (Ultramone® R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of
10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary
stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity
index, on the 1st, 7th, 15th, and 30th days after preparation and stored at different temperatures (5 ± 2 °C,
25 ± 2 °C, and 40 ± 2 °C). The anti-inflammatory in vivo activity of both oil and formulation were
evaluated, using the experimental model of croton oil-induced ear edema. The preliminary stability test
showed that the microemulsion stored at 5 and 25 °C retained its original features throughout the 30-
day period. The anti-inflammatory potential of both oil and formulation was shown to be statistically
significant (p < 0.001), when compared to the control group, however, the microemulsion proved to be
more effective (p < 0.05) than the oil when applied directly to the ear.
Descrição
Palavras-chave
Pterodon emarginatus/pharmacognosy, Pterodon emarginatus/óleo/atividade anti inflamatória, Tecnologia farmacêutica, Microemulsão, Fitoterápico, Plantas medicinais
Citação
PASCOA, Henrique; DINIZ, Danielle Guimarães Almeida; FLORENTINO, Iziara Ferreira ; COSTA, Elson Alves; BARA, Maria Teresa Freitas. Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 51, n. 1, p. 117-125, Jan./Mar. 2015.