Estudo da encapsulação da isotretinoína em lipossomas
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Data
2007-06
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Editor
Marize Campos Valadares
Resumo
Liposome vesicles are able to encapsulate hydrophilic and lipophilic substances, either in their lipid
bilayer or in the inner aqueous compartment. Retinoids are among the several drug classes whose encapsulation into
liposomes might result in potential positive results. In this work, isotretinoin encapsulation into liposomes was studies.
Liposomes were prepared by the chloroform injection method, with further characterization by dynamic light scattering.
Encapsulation efficiency was determined by UV spectrophotometry. It was observed that when liposomes were made
with 40mM of phosphatidylcholine and 10 mM of cholesterol, the encapsulation efficiency was reduced when
compared to PC liposomes, since both molecules are included in the lipid bilayer.
Descrição
Palavras-chave
Lipossomas, Isotretinoína, Encapsulação, Liposomes, Isotretinoin, Encapsulation
Citação
ALVES, Carina Pimentel Itapema; DINIZ, Danielle Guimarães Almeida; LIMA, Eliana Martins. Estudo da encapsulação da isotretinoína em
Lipossomas. Revista Eletrônica de Farmácia, Goiânia, v. 4, n. 1, jan./jun. 2007. Disponível em: <https://www.revistas.ufg.br/REF/article/view/2124/2071>.