Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)

Medina, Rebeca Previate; Moura, Vagner Marques de; Silva, Cleuza Conceição da; Oliveira, Cecilia Maria Alves de; Kato, Lucilia; Pomini, Armando Mateus; Carvalho, João Ernesto de; Gois Ruiz, Ana Lúcia Tasca; Amado, Ciomar Aparecida Bersani; Oliveira, Silvana Maria de

Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)

Data

2018

Autores

Medina, Rebeca Previate

Moura, Vagner Marques de

Silva, Cleuza Conceição da

Oliveira, Cecilia Maria Alves de

Kato, Lucilia

Pomini, Armando Mateus

Carvalho, João Ernesto de

Gois Ruiz, Ana Lúcia Tasca

Amado, Ciomar Aparecida Bersani

Oliveira, Silvana Maria de

Resumo

The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.

Palavras-chave

Ixora brevifolia, Rubiaceae, Antiproliferative activity, Anti-inflammatory activity

Citação

MEDINA, Rebeca P. et al. Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae). Natural Product Research, Abingdon, v. 32, n. 11, p. 1357-1360, 2018. DOI: 10.1080/14786419.2017.1344654. Disponível em: https://www.tandfonline.com/doi/full/10.1080/14786419.2017.1344654. Acesso em: 28 ago. 2023.