Intrinsic denervation of the colon is associated with a decrease of some colonic preneoplastic markers in rats treated with a chemical carcinogen

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dc.creatorVespúcio, Marcelo Vinícius Oliveira
dc.creatorTuratti, Aline
dc.creatorModiano, Patrícia
dc.creatorOliveira, Enio Chaves de
dc.creatorChicote, Sérgio Renato Macedo
dc.creatorCorrado, Alexandre Pinto
dc.creatorGarcia, Sérgio Britto
dc.date.accessioned2019-02-06T11:20:25Z
dc.date.available2019-02-06T11:20:25Z
dc.date.issued2008
dc.description.abstractDenervation of the colon is protective against the colon cancer; however, the mechanisms involved are unknown. We tested the hypothesis that the denervated colonic mucosa could be less responsive to the action of the chemical carcinogen dimethylhy- drazine (DMH). Three groups of 32 male Wistar rats were treated as follows: group 1 (G1) had the colon denervated with 0.3 mL 1.5 mM benzyldimethyltetradecylammonium (benzalkonium chloride, BAC); G2 received a single ip injection of 125 mg/kg DMH; G3 was treated with BAC + the same dose and route of DMH. A control group (Sham, N = 32) did not receive any treatment. Each group was subdivided into four groups according to the sacrifice time (1, 2, 6, and 12 weeks after DMH). Crypt fission index, ß- catenin accumulated crypts, aberrant crypt foci, and cell proliferation were evaluated and analyzed by ANOVA and the Student t-test. G3 animals presented a small number of aberrant crypt foci and low crypt fission index compared to G2 animals after 2 and 12 weeks, respectively. From the second week on, the index of ß-catenin crypt in G3 animals increased slower than in G2 animals. From the 12th week on, G2 animals presented a significant increase in cell proliferation when compared to the other groups. Colonic denervation plays an anticarcinogenic role from early stages of colon cancer development. This finding can be of importance for the study of the role of the enteric nervous system in the carcinogenic processpt_BR
dc.identifier.citationVESPUCIO, M. V. O. et al. Intrinsic denervation of the colon is associated with a decrease of some colonic preneoplastic markers in rats treated with a chemical carcinogen. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 41, n. 4, p. 1-7, 2008.pt_BR
dc.identifier.doi10.1590/S0100-879X2008005000008
dc.identifier.issn0100-879X
dc.identifier.issne- 1414-431X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16980
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectColon cancerpt_BR
dc.subjectMegacolonpt_BR
dc.subjectDimethylhydrazinept_BR
dc.subjectß-cateninpt_BR
dc.subjectBenzalkonium chloridept_BR
dc.subjectAberrant crypt focipt_BR
dc.titleIntrinsic denervation of the colon is associated with a decrease of some colonic preneoplastic markers in rats treated with a chemical carcinogenpt_BR
dc.typeArtigopt_BR

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