Molecular and neuroendocrine mechanisms of cancer cachexia
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Data
2015
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Resumo
Cancer and its morbidities, such as cancer cachexia, constitute a major public health problem.
Although cancer cachexia has afflicted humanity for centuries, its underlying multifactorial
and complex physiopathology has hindered the understanding of its mechanism. During the
last few decades we have witnessed a dramatic increase in the understanding of cancer
cachexia pathophysiology. Anorexia and muscle and adipose tissue wasting are the main
features of cancer cachexia. These apparently independent symptoms have humoral factors
secreted by the tumor as a common cause. Importantly, the hypothalamus has emerged as an
organ that senses the peripheral signals emanating from the tumoral environment, and not
only elicits anorexia but also contributes to the development of muscle and adipose tissue
loss. Herein, we review the roles of factors secreted by the tumor and its effects on the
hypothalamus, muscle and adipose tissue, as well as highlighting the key targets that are
being exploited for cancer cachexia treatment.
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Palavras-chave
Hypothalamus, Neuroendocrinology, Cancer, Muscle, Neuropeptides
Citação
MENDES, Maria Carolina S. et al. Molecular and neuroendocrine mechanisms of cancer cachexia. Journal of Endocrinology, Bristol, v. 226, n. 3, p. 1, 2015.