Molecular and neuroendocrine mechanisms of cancer cachexia

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dc.creatorMendes, Maria Carolina Santos
dc.creatorPimentel, Gustavo Duarte
dc.creatorCosta, Felipe O.
dc.creatorCarvalheira, José Barreto Campello
dc.date.accessioned2022-01-20T11:54:44Z
dc.date.available2022-01-20T11:54:44Z
dc.date.issued2015
dc.description.abstractCancer and its morbidities, such as cancer cachexia, constitute a major public health problem. Although cancer cachexia has afflicted humanity for centuries, its underlying multifactorial and complex physiopathology has hindered the understanding of its mechanism. During the last few decades we have witnessed a dramatic increase in the understanding of cancer cachexia pathophysiology. Anorexia and muscle and adipose tissue wasting are the main features of cancer cachexia. These apparently independent symptoms have humoral factors secreted by the tumor as a common cause. Importantly, the hypothalamus has emerged as an organ that senses the peripheral signals emanating from the tumoral environment, and not only elicits anorexia but also contributes to the development of muscle and adipose tissue loss. Herein, we review the roles of factors secreted by the tumor and its effects on the hypothalamus, muscle and adipose tissue, as well as highlighting the key targets that are being exploited for cancer cachexia treatment.pt_BR
dc.identifier.citationMENDES, Maria Carolina S. et al. Molecular and neuroendocrine mechanisms of cancer cachexia. Journal of Endocrinology, Bristol, v. 226, n. 3, p. 1, 2015.pt_BR
dc.identifier.doi10.1530/JOE-15-0170
dc.identifier.issn0022-0795
dc.identifier.issne- 1479-6805
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/20193
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentFaculdade de Nutrição - FANUT (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHypothalamuspt_BR
dc.subjectNeuroendocrinologypt_BR
dc.subjectCancerpt_BR
dc.subjectMusclept_BR
dc.subjectNeuropeptidespt_BR
dc.titleMolecular and neuroendocrine mechanisms of cancer cachexiapt_BR
dc.typeArtigopt_BR

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