Computational drug discovery for the Zika virus
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2018
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Resumo
Few Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent
epidemics occurred in South America (2014/2015) and expeditiously became a global public health
emergency. This arbovirus reached 0.5-1.3 million cases of ZIKV infection in Brazil in 2015 and rapidly
spread in new geographic areas such as the Americas. Despite the mild symptoms of the Zika fever, the
major concern is related to the related severe neurological disorders, especially microcephaly in newborns.
Advances in ZIKV drug discovery have been made recently and constitute promising approaches to
ZIKV treatment. In this review, we summarize current computational drug discovery efforts and their
applicability to discovery of anti-ZIKV drugs. Lastly, we present successful examples of the use of
computational approaches to ZIKV drug discovery.
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Zika, Flavivirus, Antiviral, Computer-assisted drug design, Virtual screening, Drug discovery
Citação
MOTTIN, Melina et al. Computational drug discovery for the Zika virus. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 54, e01002, 2018. Edição especial. DOI: 10.1590/s2175-97902018000001002. Disponível em: https://www.scielo.br/j/bjps/a/yMZVvMKDLkT6bCdbkyFRhfJ/?lang=en. Acesso em: 8 nov. 2024.