Computational drug discovery for the Zika virus

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dc.creatorMottin, Melina
dc.creatorBorba, Joyce Villa Verde Bastos
dc.creatorMelo Filho, Cleber Camilo
dc.creatorNeves, Bruno Junior
dc.creatorMuratov, Eugene
dc.creatorTorres, Pedro Henrique Monteiro
dc.creatorBraga, Rodolpho de Campos
dc.creatorPerryman, Alexander Luke
dc.creatorEkins, Sean
dc.creatorAndrade, Carolina Horta
dc.date.accessioned2024-11-18T13:46:18Z
dc.date.available2024-11-18T13:46:18Z
dc.date.issued2018
dc.description.abstractFew Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent epidemics occurred in South America (2014/2015) and expeditiously became a global public health emergency. This arbovirus reached 0.5-1.3 million cases of ZIKV infection in Brazil in 2015 and rapidly spread in new geographic areas such as the Americas. Despite the mild symptoms of the Zika fever, the major concern is related to the related severe neurological disorders, especially microcephaly in newborns. Advances in ZIKV drug discovery have been made recently and constitute promising approaches to ZIKV treatment. In this review, we summarize current computational drug discovery efforts and their applicability to discovery of anti-ZIKV drugs. Lastly, we present successful examples of the use of computational approaches to ZIKV drug discovery.
dc.identifier.citationMOTTIN, Melina et al. Computational drug discovery for the Zika virus. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 54, e01002, 2018. Edição especial. DOI: 10.1590/s2175-97902018000001002. Disponível em: https://www.scielo.br/j/bjps/a/yMZVvMKDLkT6bCdbkyFRhfJ/?lang=en. Acesso em: 8 nov. 2024.
dc.identifier.doi10.1590/s2175-97902018000001002
dc.identifier.issne- 2175-9790
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/25884
dc.language.isoeng
dc.publisher.countryBrasil
dc.publisher.departmentFaculdade de Farmácia - FF (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectZika
dc.subjectFlavivirus
dc.subjectAntiviral
dc.subjectComputer-assisted drug design
dc.subjectVirtual screening
dc.subjectDrug discovery
dc.titleComputational drug discovery for the Zika virus
dc.typeArtigo

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