Treament and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiânia, Goiás State, Brazil: a randomized controlled trial
Data
2008
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Resumo
The objective of this study was to assess the
prevalence of anemia and the therapeutic and
prophylactic response to ferrous sulfate and fo lic acid. A double-blind, randomized, controlled
clinical trial was conducted with 196 children 6
to 24 months of age enrolled in municipal day care centers in Goiânia, Goiás State, Brazil. The
children were assigned to two treatment groups
that received a daily dose (5 times a week) of ei ther 4.2mg/kg/day of ferrous sulfate + folic acid
(50µg) or 4.2mg/kg/day of ferrous sulfate + fo lic acid placebo. One of the prevention groups
received 1.4mg/kg/day of ferrous sulfate + folic
acid (50µg/day) and the other 1.4mg/kg/day of
ferrous sulfate + folic acid placebo. Supplemen tation lasted approximately three months. Base line anemia prevalence was 56.1% (95%CI: 48.9-
63.1). After treatment, anemia prevalence in the
folic acid group (14%) was lower than in the
placebo group (34.9%) (p = 0.02). After prophy laxis in the non-anemic children, the incidence
of anemia did not differ between the groups, but
there was an increase in hemoglobin level in the
folic acid group (p = 0.003). Iron plus folic acid
was effective for the treatment of anemia and
improvement of hemoglobin level in non-ane mic children.
Descrição
Palavras-chave
Nutritional epidemiology, Child day care centers, Anemia, Ferrous sulfate, Folic acid
Citação
HADLER, Maria Claret Costa Monteiro et al. Treament and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiânia, Goiás State, Brazil: a randomized controlled trial. Cadernos de Saúde Pública, Rio de Janeiro, v. 24, supl. 2, p. S259-S271, 2008.