European ancestry predominates in neuromielitis optica and multiple sclerosis patients from Brazil

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dc.creatorSouza, Doralina Guimarães Brum
dc.creatorLuizon, Marcelo Rizzatti
dc.creatorSantos, Antonio Carlos dos
dc.creatorPeixoto, Marco Aurélio Lana
dc.creatorRocha, Cristiane Franklin
dc.creatorCruz, Maria Lucia Brito da
dc.creatorOliveira, Enedina Maria Lobato de
dc.creatorBichuetti, Denis Bernardi
dc.creatorGabbai, Alberto Alain
dc.creatorDiniz, Denise Sisterolli
dc.creatorKaimen-Maciel, Damacio Ramón
dc.creatorFrota, Elizabeth Regina Comini
dc.creatorWiezel, Cláudia Emília Vieira
dc.creatorMuniz, Yara Costa Netto
dc.creatorCosta, Roberta Martins da Silva
dc.creatorMendes Junior, Celso Teixeira
dc.creatorDonadi, Eduardo Antônio
dc.creatorBarreira, Amilton Antunes
dc.creatorSimões, Aguinaldo Luiz
dc.date.accessioned2019-01-31T10:56:16Z
dc.date.available2019-01-31T10:56:16Z
dc.date.issued2013-03
dc.description.abstractBackground: Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients. Methods: Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirão Preto (NMO-RP). Principal Findings: European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population. Conclusions: Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil.pt_BR
dc.identifier.citationBRUM, Doralina Guimarães Brum et al. European ancestry predominates in neuromielitis optica and multiple sclerosis patients from Brazil. Plos One, San Francisco, v. 8, n. 3, p. e58925, 2013.pt_BR
dc.identifier.doi10.1371/journal.pone.0058925
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16909
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleEuropean ancestry predominates in neuromielitis optica and multiple sclerosis patients from Brazilpt_BR
dc.typeArtigopt_BR

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