European ancestry predominates in neuromielitis optica and multiple sclerosis patients from Brazil
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2013-03
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Background: Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis
(MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has
used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients.
Methods: Twelve AIMs were selected based on the large allele frequency differences among European, African, and
Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS
and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the
Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as
healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions,
including Ribeirão Preto (NMO-RP).
Principal Findings: European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In
contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal
component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the
European ancestral population.
Conclusions: Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from
Brazil.
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BRUM, Doralina Guimarães Brum et al. European ancestry predominates in neuromielitis optica and multiple sclerosis patients from Brazil. Plos One, San Francisco, v. 8, n. 3, p. e58925, 2013.