Diversity of anti-haemostatic proteins in the salivary glands of Rhodnius species transmitters of Chagas disease in the greater Amazon

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dc.creatorMaranhão, Ana Carolina Bussacos
dc.creatorNakayasub, Ernesto S.
dc.creatorHecht, Mariana Machado
dc.creatorRocha, Juliana Alves Parente
dc.creatorSoares, Célia Maria de Almeida
dc.creatorTeixeira, Antônio R. L.
dc.creatorAlmeida, Igor Correia de
dc.date.accessioned2020-02-11T10:41:44Z
dc.date.available2020-02-11T10:41:44Z
dc.date.issued2011
dc.description.abstractThe triatomines in the tribe Rhodniini are the main vectors of the Trypanosoma cruzi to humans in recent outbreaks of acute Chagas disease in the Amazon. These insects dwelling in palm trees do not colonize the human domicile. Their success to transmit the infection relies partially on the efficacy of their salivary gland apparatuses. Here we show the transcriptome of the Rhodnius brethesi and Rhodnius robustus salivary glands, comprising 56 and 122 clusters, respectively. Approximately one third of these clusters are described for the first time. The LC–MS/MS analysis identified 123 and 111 proteins in R. brethesi and R. robustus sialome, respectively. Noteworthy, lipocalin platelet aggregation inhibitors, inositol polyphosphate 5-phosphatases, and Kazal domain proteins, which are essential for the insect's successful acquisition of blood meals, were found in our analysis. Moreover, glutathione S transferase and antigen-5, which play roles in the insect's defense and resistance against insecticide, were also observed.pt_BR
dc.identifier.citationBUSSACOS, Ana C. M. et al. Diversity of anti-haemostatic proteins in the salivary glands of Rhodnius species transmitters of Chagas disease in the greater Amazon. Journal of Proteomics, Amsterdam, v. 74, n. 9, p. 1664-1672, 2011.pt_BR
dc.identifier.doi10.1016/j.jprot.2011.06.022
dc.identifier.issn1664-302X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18630
dc.language.isoengpt_BR
dc.publisher.countryOutrospt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHaematophagous insectspt_BR
dc.subjectProteomicspt_BR
dc.subjectSalivary glandspt_BR
dc.subjectTranscriptomicspt_BR
dc.subjectSalivary glandspt_BR
dc.subjectTranscriptomicpt_BR
dc.titleDiversity of anti-haemostatic proteins in the salivary glands of Rhodnius species transmitters of Chagas disease in the greater Amazonpt_BR
dc.typeArtigopt_BR

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