Diversity of anti-haemostatic proteins in the salivary glands of Rhodnius species transmitters of Chagas disease in the greater Amazon
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Data
2011
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Resumo
The triatomines in the tribe Rhodniini are the main vectors of the Trypanosoma cruzi to
humans in recent outbreaks of acute Chagas disease in the Amazon. These insects dwelling
in palm trees do not colonize the human domicile. Their success to transmit the infection
relies partially on the efficacy of their salivary gland apparatuses. Here we show the
transcriptome of the Rhodnius brethesi and Rhodnius robustus salivary glands, comprising 56
and 122 clusters, respectively. Approximately one third of these clusters are described for
the first time. The LC–MS/MS analysis identified 123 and 111 proteins in R. brethesi and R.
robustus sialome, respectively. Noteworthy, lipocalin platelet aggregation inhibitors, inositol
polyphosphate 5-phosphatases, and Kazal domain proteins, which are essential for the
insect's successful acquisition of blood meals, were found in our analysis. Moreover,
glutathione S transferase and antigen-5, which play roles in the insect's defense and
resistance against insecticide, were also observed.
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Haematophagous insects, Proteomics, Salivary glands, Transcriptomics, Salivary glands, Transcriptomic
Citação
BUSSACOS, Ana C. M. et al. Diversity of anti-haemostatic proteins in the salivary glands of Rhodnius species transmitters of Chagas disease in the greater Amazon. Journal of Proteomics, Amsterdam, v. 74, n. 9, p. 1664-1672, 2011.