Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4 nanoparticles

Resumo

Background: We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. Methods: We employed the ACB system, gel electrophoresis and mass spectrometry analysis. Results: Higher CP formation led to a greater reduction in the in vitro ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time in vivo among the MNPs studied. Conclusion: These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs.

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PRÓSPERO, Andre Gonçalves et al. Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe 2 O 4 nanoparticles. Nanomedicine, London, v. 16, n. 24, p. 2189-2206, 2021. DOI: 10.2217/nnm-2021-0195. Disponúvel em: https://www.futuremedicine.com/doi/10.2217/nnm-2021-0195?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed. Acesso em: 12 set. 2023.